Xenobiotic receptor meets NF-kappaB, a collision in the small bowel

Cell Metab. 2006 Sep;4(3):177-8. doi: 10.1016/j.cmet.2006.08.004.

Abstract

It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-kappaB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al.,).

Publication types

  • Review

MeSH terms

  • Animals
  • Immune Tolerance / genetics
  • Immune Tolerance / immunology*
  • Inflammation / chemically induced
  • Inflammation / genetics
  • Inflammation / immunology*
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Intestine, Small / drug effects
  • Intestine, Small / immunology*
  • Intestine, Small / physiopathology
  • Male
  • NF-kappa B / metabolism*
  • Pregnane X Receptor
  • Receptors, Steroid / metabolism*
  • Repressor Proteins / immunology
  • Repressor Proteins / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Signal Transduction / immunology
  • Transcriptional Activation / genetics
  • Transcriptional Activation / immunology
  • Xenobiotics / adverse effects
  • Xenobiotics / immunology
  • Xenobiotics / metabolism*

Substances

  • Inflammation Mediators
  • NF-kappa B
  • Pregnane X Receptor
  • Receptors, Steroid
  • Repressor Proteins
  • Xenobiotics