The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

Hiroshi Omote; Miki Hiasa; Takuya Matsumoto; Masato Otsuka; Yoshinori Moriyama

doi:10.1016/j.tips.2006.09.001

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

Trends Pharmacol Sci. 2006 Nov;27(11):587-93. doi: 10.1016/j.tips.2006.09.001. Epub 2006 Sep 25.

Authors

Hiroshi Omote¹, Miki Hiasa, Takuya Matsumoto, Masato Otsuka, Yoshinori Moriyama

Affiliation

¹ Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan.

PMID: 16996621
DOI: 10.1016/j.tips.2006.09.001

Abstract

Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs, such as norfloxacin and ethidium, through H(+) or Na(+) exchange. Plant MATE-type transporters are involved in the detoxification of secondary metabolites, including alkaloids. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H(+). Thus, we propose that members of the MATE family are organic cation exporters that excrete metabolic or xenobiotic organic cations from the body.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B / chemistry
ATP Binding Cassette Transporter, Subfamily B / genetics
ATP Binding Cassette Transporter, Subfamily B / metabolism*
Amino Acid Sequence
Animals
Antiporters / chemistry
Antiporters / genetics
Antiporters / metabolism*
Arabidopsis Proteins / metabolism
Bacterial Proteins / metabolism
Biotransformation
Carrier Proteins / metabolism
Humans
Molecular Sequence Data
Organic Cation Transport Proteins / chemistry
Organic Cation Transport Proteins / genetics
Organic Cation Transport Proteins / metabolism*
Pharmaceutical Preparations / metabolism
Phylogeny
Protein Structure, Tertiary
Saccharomyces cerevisiae Proteins / metabolism
Steroids / metabolism
Transcription Factors / metabolism
Xenobiotics / metabolism*

Substances

ALF5 protein, Arabidopsis
ATP Binding Cassette Transporter, Subfamily B
Antiporters
Arabidopsis Proteins
Bacterial Proteins
Carrier Proteins
DTX1 protein, Arabidopsis
MATE1 protein, mouse
NorM protein, bacteria
Organic Cation Transport Proteins
Pharmaceutical Preparations
Saccharomyces cerevisiae Proteins
Steroids
Transcription Factors
Xenobiotics
tt12 protein, Arabidopsis