Abstract
Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters / genetics
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ATP-Binding Cassette Transporters / physiology*
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Animals
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Antineoplastic Agents / pharmacology*
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Biological Availability
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Drug Resistance, Multiple*
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Drug Resistance, Neoplasm*
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Hematopoietic Stem Cells / metabolism
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Humans
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology*
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Protein Kinase Inhibitors / pharmacology*
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Protein-Tyrosine Kinases / antagonists & inhibitors*
Substances
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ABCG2 protein, human
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters
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Antineoplastic Agents
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Neoplasm Proteins
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Protein Kinase Inhibitors
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Protein-Tyrosine Kinases