Abstract
We present a case of severe mucositis due to a drug-drug interaction between methotrexate (MTX) and omeprazole in an adolescent with Acute Lymphatic Leukemia (ALL). In view of the prevalence of MTX in many cytotoxic protocols, and the frequent use of omeprazole in the (ambulatory) oncology setting, we believe that this case-report is worth mentioning.
MeSH terms
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Adolescent
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Anti-Inflammatory Agents / therapeutic use
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Anti-Ulcer Agents / adverse effects*
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Anti-Ulcer Agents / blood
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Anti-Ulcer Agents / therapeutic use
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Antimetabolites, Antineoplastic / adverse effects*
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Antimetabolites, Antineoplastic / blood
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Antimetabolites, Antineoplastic / therapeutic use*
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Humans
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Male
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Methotrexate / adverse effects*
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Methotrexate / blood
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Methotrexate / therapeutic use*
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Omeprazole / adverse effects*
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Omeprazole / blood
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Omeprazole / therapeutic use
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Prednisolone / therapeutic use
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Ranitidine / therapeutic use
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Stomach Ulcer / chemically induced
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Stomach Ulcer / prevention & control
Substances
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Anti-Inflammatory Agents
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Anti-Ulcer Agents
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Antimetabolites, Antineoplastic
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Ranitidine
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Prednisolone
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Omeprazole
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Methotrexate