The effects of hemodilution, pH, and protamine on lidocaine plasma protein binding and red blood-cell uptake in vitro

Pharm Res. 1991 Jan;8(1):127-30. doi: 10.1023/a:1015807129129.

Authors

R P Remmel¹, A K Copa, D M Angaran

Affiliation

¹ Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.

PMID: 1901648
DOI: 10.1023/a:1015807129129

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Edetic Acid
Erythrocytes / metabolism*
Hemodilution
Humans
Hydrogen-Ion Concentration
In Vitro Techniques
Lidocaine / blood*
Lidocaine / pharmacokinetics
Protamines / blood*
Protein Binding

Substances

Protamines
Lidocaine
Edetic Acid