Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065

J Med Chem. 2009 Oct 8;52(19):5771-80. doi: 10.1021/jm9006214.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkylating Agents / chemistry
  • Alkylating Agents / pharmacology
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Duocarmycins
  • Indoles / chemistry*
  • Indoles / pharmacology*
  • Molecular Structure
  • Pyrroles / chemistry
  • Pyrroles / pharmacology
  • Structure-Activity Relationship

Substances

  • Alkylating Agents
  • Antibiotics, Antineoplastic
  • Duocarmycins
  • Indoles
  • Pyrroles
  • duocarmycin SA
  • CC 1065