Abstract
Little is known about interactions of other drugs with the recently marketed antipsychotic clozapine. Two cases in which the addition of phenytoin caused a decrease in plasma clozapine concentrations and worsening of psychoses are described, and possible explanations are discussed.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Clozapine / adverse effects
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Clozapine / blood*
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Clozapine / therapeutic use
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Drug Interactions
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Drug Therapy, Combination
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Female
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Humans
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Male
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Phenytoin / adverse effects*
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Phenytoin / pharmacology
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Phenytoin / therapeutic use
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Psychotic Disorders / blood
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology