Organogenesis and development of the liver

Dev Cell. 2010 Feb 16;18(2):175-89. doi: 10.1016/j.devcel.2010.01.011.

Abstract

Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic functions. Here, we review the basic molecular mechanisms that control the formation of the liver as an organ.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biliary Tract / embryology
  • Biliary Tract / metabolism
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Endothelial Cells / cytology
  • Endothelial Cells / metabolism
  • Hematopoiesis
  • Hepatic Stellate Cells / cytology
  • Hepatic Stellate Cells / metabolism
  • Hepatocytes / cytology
  • Hepatocytes / metabolism
  • Humans
  • Kupffer Cells / cytology
  • Kupffer Cells / metabolism
  • Liver / blood supply
  • Liver / cytology
  • Liver / embryology*
  • Liver / metabolism
  • Mice
  • Signal Transduction
  • Transcription, Genetic