Objective: To study the change of endogenous metabolites of SD rats administrated of aqueous extract of Evodiae rutaecarpa.
Method: Six SD rats had been successively administrated aqueous extract of E. rutaecarpa (0.3857 g x kg(-1)) for 33 days. An agilent 1200 6410 triplequadrupole mass spectrometer was used for the analysis of endogenous metabolites in rat urine samples. These data was analyzed by the principal component analysis (PCA) and PLS-DA using the SIMCA-P 10.0 software.
Result: The significant difference in metabolic profiles between the control group and the dosed group was well observed by PCA of the MS data.
Conclusion: The E. rulaecarpa has changed the endogenous metabolites of SD rats. This work can provide the base for the further research on the interpretation of drug property of E. rulaecarpa.