Abstract
The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described.
2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylating Agents / chemical synthesis*
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Alkylating Agents / chemistry
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Alkylating Agents / toxicity
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Animals
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Cell Line, Tumor
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DNA / chemistry
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Duocarmycins
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Indoles / chemical synthesis
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Indoles / chemistry*
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Indoles / toxicity
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Mice
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / toxicity
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Structure-Activity Relationship
Substances
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Alkylating Agents
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Duocarmycins
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Indoles
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Pyrroles
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duocarmycin SA
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DNA