Transcriptional and epigenetic regulation of human microRNAs

Zifeng Wang; Hong Yao; Sheng Lin; Xiao Zhu; Zan Shen; Gang Lu; Wai Sang Poon; Dan Xie; Marie Chia-mi Lin; Hsiang-fu Kung

doi:10.1016/j.canlet.2012.12.006

Transcriptional and epigenetic regulation of human microRNAs

Cancer Lett. 2013 Apr 30;331(1):1-10. doi: 10.1016/j.canlet.2012.12.006. Epub 2012 Dec 11.

Authors

Zifeng Wang¹, Hong Yao, Sheng Lin, Xiao Zhu, Zan Shen, Gang Lu, Wai Sang Poon, Dan Xie, Marie Chia-mi Lin, Hsiang-fu Kung

Affiliation

¹ Brain Tumour Centre and Division of Neurosurgery, Department of Surgery, Chinese University of Hong Kong, Hong Kong.

PMID: 23246373
DOI: 10.1016/j.canlet.2012.12.006

Abstract

MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Epigenomics*
Gene Expression Regulation*
Humans
MicroRNAs / genetics*
Neoplasms / genetics*
Transcription, Genetic*

Substances

MicroRNAs