Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes

Clin Pharmacol Ther. 2014 Mar;95(3):258-61. doi: 10.1038/clpt.2013.220. Epub 2013 Nov 6.

Authors

U M Zanger¹, K Klein¹, M Thomas¹, J K Rieger¹, R Tremmel¹, B A Kandel¹, M Klein¹, T Magdy¹

Affiliation

¹ 1] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany [2] University of Tuebingen, Tuebingen, Germany.

PMID: 24196843
DOI: 10.1038/clpt.2013.220

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cytochrome P-450 Enzyme System / genetics*
Cytochrome P-450 Enzyme System / metabolism*
Drug Discovery / methods*
Drug Discovery / trends
Epigenomics / trends*
Gene Expression Regulation, Enzymologic / genetics
Genetic Variation
Genetics / trends*
Humans
Isoenzymes / genetics
Polymorphism, Single Nucleotide

Substances

Isoenzymes
Cytochrome P-450 Enzyme System