Abstract
This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.
MeSH terms
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Cytochrome P-450 Enzyme Inhibitors
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Cytochrome P-450 Enzyme System / metabolism
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Drug Design
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Drug Interactions
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Enzyme Inhibitors / pharmacology*
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Enzymes / metabolism*
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Humans
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Kinetics
Substances
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Cytochrome P-450 Enzyme Inhibitors
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Enzyme Inhibitors
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Enzymes
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Cytochrome P-450 Enzyme System