The "psychomicrobiotic": Targeting microbiota in major psychiatric disorders: A systematic review

G Fond; W Boukouaci; G Chevalier; A Regnault; G Eberl; N Hamdani; F Dickerson; A Macgregor; L Boyer; A Dargel; J Oliveira; R Tamouza; M Leboyer

doi:10.1016/j.patbio.2014.10.003

The "psychomicrobiotic": Targeting microbiota in major psychiatric disorders: A systematic review

Pathol Biol (Paris). 2015 Feb;63(1):35-42. doi: 10.1016/j.patbio.2014.10.003. Epub 2014 Nov 2.

Authors

G Fond¹, W Boukouaci², G Chevalier³, A Regnault⁴, G Eberl³, N Hamdani⁵, F Dickerson⁶, A Macgregor⁷, L Boyer⁸, A Dargel⁵, J Oliveira², R Tamouza², M Leboyer⁵

Affiliations

¹ Inserm U955, FondaMental Foundation, Paris-Est university, Chenevier Hospital, AP-HP, GHU Mondor, DHU Pe-Psy, Pavillon Hartmann, 40, rue Mesly, 94000 Créteil, France. Electronic address: guillaume.fond@gmail.com.
² Jean-Dausset Laboratory & Inserm, UMRS 940, Saint-Louis hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France.
³ Unité de développement du tissu lymphoïde, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, France.
⁴ Inserm, Institut Pasteur, aviesan/institut multi-organismes immunologie, hématologie et pneumologie (ITMO IHP), bâtiment Biopark, 8, rue de la Croix Jarry 1(er) étage, 75013 Paris, France.
⁵ Inserm U955, FondaMental Foundation, Paris-Est university, Chenevier Hospital, AP-HP, GHU Mondor, DHU Pe-Psy, Pavillon Hartmann, 40, rue Mesly, 94000 Créteil, France.
⁶ Stanley Research Program, Sheppard Pratt Health System, 6501N, Charles Street, MD 21204 Baltimore, United States.
⁷ Inserm U1061, academic adult psychiatry department, Montpellier 1 university, La Colombière hospital, Montpellier CHRU, 191, avenue du doyen Gaston-Giraud, 34295 Montpellier cedex, France.
⁸ EA 3279-Self-perceived Health Assessment Research Unit, School of Medicine, La Timone University, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France.

PMID: 25468489
DOI: 10.1016/j.patbio.2014.10.003

Abstract

The gut microbiota is increasingly considered as a symbiotic partner in the maintenance of good health. Metagenomic approaches could help to discover how the complex gut microbial ecosystem participates in the control of the host's brain development and function, and could be relevant for future therapeutic developments, such as probiotics, prebiotics and nutritional approaches for psychiatric disorders. Previous reviews focused on the effects of microbiota on the central nervous system in in vitro and animal studies. The aim of the present review is to synthetize the current data on the association between microbiota dysbiosis and onset and/or maintenance of major psychiatric disorders, and to explore potential therapeutic opportunities targeting microbiota dysbiosis in psychiatric patients.

Keywords: Anxiety; Anxiété; Autism; Autisme; Axe intestin-cerveau; Dépression; Microbiota dysbiosis; Microbiote; Métagénome; Probiotic; Probiotique; Prébiotique; Schizophrenia; Thérapeutique; Traitement.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Animals
Dietary Supplements
Drug Delivery Systems / methods
Dysbiosis / complications
Dysbiosis / diet therapy*
Dysbiosis / microbiology
Humans
Mental Disorders / complications
Mental Disorders / diet therapy*
Mental Disorders / microbiology
Microbiota / drug effects*
Prebiotics* / administration & dosage
Probiotics / therapeutic use*

Substances

Prebiotics