Investigation of the mechanism of the metabolic activation of chloramphenicol by rat liver microsomes. Identification of a new metabolite

Biochem Pharmacol. 1978 Feb 15;27(4):491-6. doi: 10.1016/0006-2952(78)90383-0.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biotransformation
  • Chloramphenicol / analogs & derivatives
  • Chloramphenicol / chemical synthesis
  • Chloramphenicol / metabolism*
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Hydrolysis
  • In Vitro Techniques
  • Male
  • Mass Spectrometry
  • Microsomes, Liver / metabolism*
  • Oxamic Acid / analogs & derivatives
  • Oxamic Acid / chemical synthesis
  • Oxamic Acid / metabolism
  • Radioisotope Dilution Technique
  • Rats

Substances

  • Chloramphenicol
  • Oxamic Acid