Abstract
Plasma and abomasal fluid concentrations of fenbendazole and its two major metabolites in sheep experimentally infected with Ostertagia circumcincta were compared with those in the same sheep when non-parasitised. Bio-availability of the drug was reduced in the parasitised state. There was also a reduction in the proportion of drug present in the form of metabolites in parasitised as compared with non-parasitised animals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abomasum / metabolism
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Animals
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Benzimidazoles / metabolism*
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Biological Availability
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Fenbendazole / blood
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Fenbendazole / metabolism*
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Fenbendazole / therapeutic use
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Hydrogen-Ion Concentration
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Kinetics
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Ostertagiasis / blood
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Ostertagiasis / drug therapy
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Ostertagiasis / metabolism
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Ostertagiasis / veterinary*
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Pepsinogens / blood
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Sheep / parasitology
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Sheep Diseases / blood
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Sheep Diseases / drug therapy
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Sheep Diseases / metabolism*
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Sulfones / metabolism
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Trichostrongyloidiasis / veterinary*
Substances
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Benzimidazoles
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Pepsinogens
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Sulfones
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Fenbendazole
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oxfendazole