Abstract
The renal handling of cis-diamminedichloroplatinum(II) (cisplatin) was investigated by measuring the renal clearance of creatinine and free platinum (Pt). Free Pt clearance exceeded the glomerular filtration rate, indicating secretion of cisplatin or a metabolite. These results suggest that accumulation of Pt within renal tubular cells may be related to its nephrotoxicity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cisplatin / metabolism*
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Cisplatin / urine
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Creatinine / metabolism
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Female
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Glomerular Filtration Rate
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Head and Neck Neoplasms / drug therapy
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Head and Neck Neoplasms / metabolism
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Humans
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Kidney / drug effects
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Kidney / metabolism*
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Male
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Metabolic Clearance Rate
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Middle Aged
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Platinum / blood
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Platinum / urine
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Time Factors
Substances
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Platinum
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Creatinine
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Cisplatin