Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):420. doi: 10.1159/000237063.

Authors

N Yumibe¹, K Huie, K J Chen, R P Clement, M N Cayen

Affiliation

¹ Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Lafayette, NJ 07848-0032, USA.

PMID: 7613198
DOI: 10.1159/000237063

No abstract available

MeSH terms

Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System / metabolism*
Humans
Inactivation, Metabolic
Loratadine / pharmacokinetics*
Microsomes, Liver / enzymology*
Mixed Function Oxygenases / antagonists & inhibitors
Mixed Function Oxygenases / metabolism*
Piperidines / metabolism
Pyridines / metabolism

Substances

Cytochrome P-450 Enzyme Inhibitors
Piperidines
Pyridines
Loratadine
Cytochrome P-450 Enzyme System
Mixed Function Oxygenases
CYP3A protein, human
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
desloratadine