Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy

Mol Carcinog. 1995 Jul;13(3):129-34. doi: 10.1002/mc.2940130302.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / metabolism
  • Aryl Hydrocarbon Hydroxylases*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / metabolism*
  • Drug Resistance, Multiple
  • Epoxide Hydrolases / metabolism
  • Gene Expression
  • Glutathione Transferase / metabolism
  • Humans
  • Liver / metabolism
  • Neoplasms / drug therapy*
  • Oxidoreductases, N-Demethylating / metabolism*
  • Substrate Specificity
  • Tissue Distribution

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Cytochrome P-450 Enzyme System
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP3A
  • Oxidoreductases, N-Demethylating
  • Glutathione Transferase
  • Epoxide Hydrolases