Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria

S el-Mekkawy; M R Meselhy; Y Kawata; S Kadota; M Hattori; T Namba

doi:10.1055/s-2006-959698

Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria

Planta Med. 1993 Aug;59(4):347-50. doi: 10.1055/s-2006-959698.

Authors

S el-Mekkawy¹, M R Meselhy, Y Kawata, S Kadota, M Hattori, T Namba

Affiliation

¹ Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University.

PMID: 8103941
DOI: 10.1055/s-2006-959698

Abstract

Anaerobic incubation of strychnine N-oxide with human intestinal bacteria resulted in its transformation to strychnine and 16-hydroxystrychnine. Similarly, brucine N-oxide was transformed to brucine and 16-hydroxybrucine.

MeSH terms

Bacteria, Anaerobic / metabolism*
Cyclic N-Oxides / chemistry
Cyclic N-Oxides / metabolism*
Humans
Intestines / microbiology*
Molecular Structure
Strychnine / analogs & derivatives*
Strychnine / chemistry
Strychnine / metabolism

Substances

Cyclic N-Oxides
brucine N-oxide
strychnine N-oxide
Strychnine