Oxygen radical formation due to the effect of varying hydrogen ion concentrations on cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes

Adv Exp Med Biol. 1996:387:135-9. doi: 10.1007/978-1-4757-9480-9_19.
No abstract available

MeSH terms

  • Adrenochrome / biosynthesis
  • Animals
  • Benzphetamine / metabolism
  • Central Nervous System Stimulants / metabolism
  • Cyclosporine / metabolism*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • Hydrogen-Ion Concentration
  • Immunosuppressive Agents / metabolism*
  • In Vitro Techniques
  • Malondialdehyde / metabolism
  • Microsomes, Liver / enzymology*
  • NADH Dehydrogenase / metabolism
  • Rats
  • Reactive Oxygen Species / metabolism*

Substances

  • Central Nervous System Stimulants
  • Immunosuppressive Agents
  • Reactive Oxygen Species
  • Benzphetamine
  • Malondialdehyde
  • Adrenochrome
  • Cyclosporine
  • Cytochrome P-450 Enzyme System
  • NADH Dehydrogenase