Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

P Dalén; C Frengell; M L Dahl; F Sjöqvist

doi:10.1097/00007691-199710000-00011

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

Ther Drug Monit. 1997 Oct;19(5):543-4. doi: 10.1097/00007691-199710000-00011.

Authors

P Dalén¹, C Frengell, M L Dahl, F Sjöqvist

Affiliation

¹ Department of Medical Laboratory Sciences & Technology, Huddinge University Hospital, Sweden.

PMID: 9357099
DOI: 10.1097/00007691-199710000-00011

Abstract

The authors describe a 33-year-old woman who experienced severe pain in the epigastrium after codeine intake. This side-effect is consistent with that of morphine. Later, the patient was phenotyped and genotyped as an ultrarapid metabolizer with high capacity to metabolize codeine to morphine.

Publication types

Case Reports

MeSH terms

Abdominal Pain / chemically induced*
Abdominal Pain / metabolism
Adult
Analgesics, Opioid / adverse effects*
Analgesics, Opioid / metabolism
Codeine / adverse effects*
Codeine / metabolism*
Cytochrome P-450 CYP2D6 / metabolism*
Debrisoquin / metabolism
Female
Humans

Substances

Analgesics, Opioid
Cytochrome P-450 CYP2D6
Codeine
Debrisoquin