Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: preliminary in vitro findings using a rat liver preparation

J Pharm Sci. 1997 Dec;86(12):1494-6. doi: 10.1021/js970072x.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carboxylesterase
  • Carboxylic Ester Hydrolases / metabolism*
  • Central Nervous System Stimulants / pharmacokinetics*
  • Esterification
  • Ethanol / pharmacology*
  • In Vitro Techniques
  • Liver / drug effects*
  • Liver / enzymology
  • Male
  • Meperidine / pharmacokinetics*
  • Methylphenidate / pharmacokinetics*
  • Narcotics / pharmacokinetics*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Central Nervous System Stimulants
  • Narcotics
  • Methylphenidate
  • Ethanol
  • Meperidine
  • Carboxylic Ester Hydrolases
  • Carboxylesterase