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Page 1
Minimizing DILI risk in drug discovery - A screening tool for drug candidates.
Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):429-37. doi: 10.1016/j.tiv.2015.09.019. Epub 2015 Sep 25.
Toxicol In Vitro. 2015.
PMID: 26407524
Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.
Poirier A, Cascais AC, Funk C, Lavé T.
Poirier A, et al. Among authors: cascais ac.
Chem Biodivers. 2009 Nov;6(11):1975-87. doi: 10.1002/cbdv.200900116.
Chem Biodivers. 2009.
PMID: 19937834
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Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.
Jaramillo CAC, Belli S, Cascais AC, Dudal S, Edelmann MR, Haak M, Brun ME, Otteneder MB, Ullah M, Funk C, Schuler F, Simon S.
Jaramillo CAC, et al. Among authors: cascais ac.
MAbs. 2017 Jul;9(5):781-791. doi: 10.1080/19420862.2017.1320008. Epub 2017 Apr 25.
MAbs. 2017.
PMID: 28440708
Free PMC article.
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Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions in vivo.
Poirier A, Cascais AC, Bader U, Portmann R, Brun ME, Walter I, Hillebrecht A, Ullah M, Funk C.
Poirier A, et al. Among authors: cascais ac.
Drug Metab Dispos. 2014 Sep;42(9):1411-22. doi: 10.1124/dmd.114.057943. Epub 2014 Jun 17.
Drug Metab Dispos. 2014.
PMID: 24939652
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Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data.
Poirier A, Cascais AC, Funk C, Lavé T.
Poirier A, et al. Among authors: cascais ac.
J Pharmacokinet Pharmacodyn. 2009 Dec;36(6):585-611. doi: 10.1007/s10928-009-9139-3. Epub 2009 Nov 20.
J Pharmacokinet Pharmacodyn. 2009.
PMID: 19936896
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The need for human breast cancer resistance protein substrate and inhibition evaluation in drug discovery and development: why, when, and how?
Poirier A, Portmann R, Cascais AC, Bader U, Walter I, Ullah M, Funk C.
Poirier A, et al. Among authors: cascais ac.
Drug Metab Dispos. 2014 Sep;42(9):1466-77. doi: 10.1124/dmd.114.058248. Epub 2014 Jul 2.
Drug Metab Dispos. 2014.
PMID: 24989889
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