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Receptor occupancy and brain free fraction.
Watson J, Wright S, Lucas A, Clarke KL, Viggers J, Cheetham S, Jeffrey P, Porter R, Read KD. Watson J, et al. Among authors: clarke kl. Drug Metab Dispos. 2009 Apr;37(4):753-60. doi: 10.1124/dmd.108.022814. Epub 2009 Jan 21. Drug Metab Dispos. 2009. PMID: 19158315
SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist.
Scott C, Langmead CJ, Clarke KL, Wyman P, Smith PW, Starr KR, Dawson LA, Price GW, Hagan JJ, Watson J. Scott C, et al. Among authors: clarke kl. Neuropharmacology. 2006 Jun;50(8):984-90. doi: 10.1016/j.neuropharm.2006.01.008. Epub 2006 Mar 20. Neuropharmacology. 2006. PMID: 16546225