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Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition.
Kawamura M, Kobashi Y, Tanaka H, Bohno-Mikami A, Hamada M, Ito Y, Hirata T, Ohara H, Kojima N, Koretsune H, Gunji E, Fukunaga T, Inatani S, Hasegawa Y, Suzuki A, Takahashi T, Kakinuma H. Kawamura M, et al. Among authors: gunji e. J Med Chem. 2022 Nov 10;65(21):14599-14613. doi: 10.1021/acs.jmedchem.2c01089. Epub 2022 Nov 1. J Med Chem. 2022. PMID: 36318660
Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points.
Oka Y, Abe-Sato K, Tabuse H, Yasukawa Y, Yahara T, Nishimoto T, Kamitani M, Fukunaga T, Ochiai N, Kumasaka-Abe T, Hitaka K, Gunji E, Ohara H, Takeda T, Kojima N, Asami T. Oka Y, et al. Among authors: gunji e. J Med Chem. 2024 Jan 25;67(2):1406-1420. doi: 10.1021/acs.jmedchem.3c01967. Epub 2024 Jan 12. J Med Chem. 2024. PMID: 38214909
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
Yamamoto K, Uchida S, Kitano K, Fukuhara N, Okumura-Kitajima L, Gunji E, Kozakai A, Tomoike H, Kojima N, Asami J, Toyoda H, Arai M, Takahashi T, Takahashi K. Yamamoto K, et al. Among authors: gunji e. Br J Pharmacol. 2011 Sep;164(1):181-91. doi: 10.1111/j.1476-5381.2011.01340.x. Br J Pharmacol. 2011. PMID: 21410690 Free PMC article.
12 results