Isolation and identification of bromfenac glucoside from rat bile

Drug Metab Dispos. 1998 Jul;26(7):720-3.

Abstract

Bromfenac (Duract(R)), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of 14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside.

MeSH terms

  • Analgesics / metabolism*
  • Animals
  • Benzophenones / metabolism*
  • Bile / metabolism*
  • Bromobenzenes / metabolism*
  • Glucosides / metabolism*
  • Hydrogen-Ion Concentration
  • Male
  • Mass Spectrometry
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Analgesics
  • Benzophenones
  • Bromobenzenes
  • Glucosides
  • bromfenac