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KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.
Huskey SE, Zhu CQ, Fredenhagen A, Kühnöl J, Luneau A, Jian Z, Yang Z, Miao Z, Yang F, Jain JP, Sunkara G, Mangold JB, Stein DS. Huskey SE, et al. Among authors: kuhnol j. Drug Metab Dispos. 2016 May;44(5):672-82. doi: 10.1124/dmd.115.069187. Epub 2016 Feb 26. Drug Metab Dispos. 2016. PMID: 26921387
Complementary use of ion trap/time-of-flight mass spectrometry in combination with capillary high-pressure liquid chromatography: early characterization of in vivo metabolites of the cathepsin K inhibitor NVP-AAV490 in rat.
Blum W, Buhl T, Altmann E, Kühnöl J, Ramstein P, Aichholz R. Blum W, et al. Among authors: kuhnol j. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Apr 25;787(2):255-70. doi: 10.1016/s1570-0232(02)00782-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12650749
In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Brüggen J, O'Reilly T, Flörsheimer A. Blum W, et al. Among authors: kuhnol j. Rapid Commun Mass Spectrom. 2001;15(1):41-9. doi: 10.1002/1097-0231(20010115)15:1<41::AID-RCM190>3.0.CO;2-W. Rapid Commun Mass Spectrom. 2001. PMID: 11135423
Determination of the GABA(B) receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Froestl W, Desrayaud S. Blum W, et al. Among authors: kuhnol j. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748(2):349-59. doi: 10.1016/s0378-4347(00)00352-2. J Chromatogr B Biomed Sci Appl. 2000. PMID: 11087077