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2004 2
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Page 1
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.
Fandrick KR, Li W, Zhang Y, Tang W, Gao J, Rodriguez S, Patel ND, Reeves DC, Wu JP, Sanyal S, Gonnella N, Qu B, Haddad N, Lorenz JC, Sidhu K, Wang J, Ma S, Grinberg N, Lee H, Tsantrizos Y, Poupart MA, Busacca CA, Yee NK, Lu BZ, Senanayake CH. Fandrick KR, et al. Among authors: lorenz jc. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7144-8. doi: 10.1002/anie.201501575. Epub 2015 May 4. Angew Chem Int Ed Engl. 2015. PMID: 25939331
Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420.
Patel ND, Wei X, Byrne D, Narayanan BA, Pennino S, Sarvestani M, Saha A, Haddad N, Kapadia S, Lorenz JC, DeCroos P, Ye A, Lee H, Grinberg N, Hossain A, Busacca CA, Yee NK, Senanayake CH. Patel ND, et al. Among authors: lorenz jc. J Org Chem. 2020 Jul 2;85(13):8339-8351. doi: 10.1021/acs.joc.0c00554. Epub 2020 Jun 19. J Org Chem. 2020. PMID: 32462862
Reduction of tertiary phosphine oxides with DIBAL-H.
Busacca CA, Raju R, Grinberg N, Haddad N, James-Jones P, Lee H, Lorenz JC, Saha A, Senanayake CH. Busacca CA, et al. Among authors: lorenz jc. J Org Chem. 2008 Feb 15;73(4):1524-31. doi: 10.1021/jo7024064. Epub 2008 Jan 16. J Org Chem. 2008. PMID: 18197688
Large-scale asymmetric synthesis of a cathepsin S inhibitor.
Lorenz JC, Busacca CA, Feng X, Grinberg N, Haddad N, Johnson J, Kapadia S, Lee H, Saha A, Sarvestani M, Spinelli EM, Varsolona R, Wei X, Zeng X, Senanayake CH. Lorenz JC, et al. J Org Chem. 2010 Feb 19;75(4):1155-61. doi: 10.1021/jo9022809. J Org Chem. 2010. PMID: 20102230
Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.
Wei X, Qu B, Zeng X, Savoie J, Fandrick KR, Desrosiers JN, Tcyrulnikov S, Marsini MA, Buono FG, Li Z, Yang BS, Tang W, Haddad N, Gutierrez O, Wang J, Lee H, Ma S, Campbell S, Lorenz JC, Eckhardt M, Himmelsbach F, Peters S, Patel ND, Tan Z, Yee NK, Song JJ, Roschangar F, Kozlowski MC, Senanayake CH. Wei X, et al. Among authors: lorenz jc. J Am Chem Soc. 2016 Nov 30;138(47):15473-15481. doi: 10.1021/jacs.6b09764. Epub 2016 Nov 17. J Am Chem Soc. 2016. PMID: 27794616 Free PMC article.
20 results