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Page 1
Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia.
Reichard HA, Schiffer HH, Monenschein H, Atienza JM, Corbett G, Skaggs AW, Collia DR, Ray WJ, Serrats J, Bliesath J, Kaushal N, Lam BP, Amador-Arjona A, Rahbaek L, McConn DJ, Mulligan VJ, Brice N, Gaskin PLR, Cilia J, Hitchcock S. Reichard HA, et al. Among authors: mcconn dj. J Med Chem. 2021 Aug 12;64(15):11527-11542. doi: 10.1021/acs.jmedchem.1c00820. Epub 2021 Jul 14. J Med Chem. 2021. PMID: 34260228
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism.
Huang W, Lin YS, McConn DJ 2nd, Calamia JC, Totah RA, Isoherranen N, Glodowski M, Thummel KE. Huang W, et al. Among authors: mcconn dj 2nd. Drug Metab Dispos. 2004 Dec;32(12):1434-45. doi: 10.1124/dmd.104.001313. Epub 2004 Sep 21. Drug Metab Dispos. 2004. PMID: 15383492
Dose-related reduction in bupropion plasma concentrations by ritonavir.
Park J, Vousden M, Brittain C, McConn DJ, Iavarone L, Ascher J, Sutherland SM, Muir KT. Park J, et al. Among authors: mcconn dj. J Clin Pharmacol. 2010 Oct;50(10):1180-7. doi: 10.1177/0091270009359524. Epub 2010 May 19. J Clin Pharmacol. 2010. PMID: 20484617