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Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug.
Drug Metab Dispos. 2011 Feb;39(2):345-50. doi: 10.1124/dmd.110.034074. Epub 2010 Nov 10.
Drug Metab Dispos. 2011.
PMID: 21068193
Free PMC article.
Cytochrome P450 oxidation of the thiophene-containing anticancer drug 3-[(quinolin-4-ylmethyl)-amino]-thiophene-2-carboxylic acid (4-trifluoromethoxy-phenyl)-amide to an electrophilic intermediate.
Medower C, Wen L, Johnson WW.
Medower C, et al.
Chem Res Toxicol. 2008 Aug;21(8):1570-7. doi: 10.1021/tx700430n. Epub 2008 Aug 2.
Chem Res Toxicol. 2008.
PMID: 18672911
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