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Mechanistic in vitro studies indicate that the clinical drug-drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3.
Elsby R, Coghlan H, Edgerton J, Hodgson D, Outteridge S, Atkinson H. Elsby R, et al. Among authors: outteridge s. Pharmacol Res Perspect. 2023 Apr;11(2):e01060. doi: 10.1002/prp2.1060. Pharmacol Res Perspect. 2023. PMID: 36811234 Free PMC article.
Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1.
Elsby R, Hare V, Neal H, Outteridge S, Pearson C, Plant K, Gill RU, Butler P, Riley RJ. Elsby R, et al. Among authors: outteridge s. Drug Metab Dispos. 2019 Jan;47(1):1-8. doi: 10.1124/dmd.118.083832. Epub 2018 Oct 22. Drug Metab Dispos. 2019. PMID: 30348903
Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.
Thomas MR, Outteridge SN, Ajjan RA, Phoenix F, Sangha GK, Faulkner RE, Ecob R, Judge HM, Khan H, West LE, Dockrell DH, Sabroe I, Storey RF. Thomas MR, et al. Among authors: outteridge sn. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2562-70. doi: 10.1161/ATVBAHA.115.306528. Epub 2015 Oct 29. Arterioscler Thromb Vasc Biol. 2015. PMID: 26515417 Free PMC article. Clinical Trial.
Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, Jones H, Butler P. Elsby R, et al. Among authors: outteridge s. Pharmacol Res Perspect. 2017 Oct;5(5):e00357. doi: 10.1002/prp2.357. Pharmacol Res Perspect. 2017. PMID: 28971610 Free PMC article.