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Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance.
Palacharla RC, Uthukam V, Manoharan A, Ponnamaneni RK, Padala NP, Boggavarapu RK, Bhyrapuneni G, Ajjala DR, Nirogi R. Palacharla RC, et al. Among authors: ponnamaneni rk. Eur J Pharm Sci. 2017 Apr 1;101:80-89. doi: 10.1016/j.ejps.2017.01.027. Epub 2017 Feb 4. Eur J Pharm Sci. 2017. PMID: 28179134
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
Nirogi R, Palacharla RC, Mohammed AR, Manoharan A, Ponnamaneni RK, Bhyrapuneni G. Nirogi R, et al. Among authors: ponnamaneni rk. Chem Biol Interact. 2015 Mar 25;230:9-20. doi: 10.1016/j.cbi.2015.01.028. Epub 2015 Feb 3. Chem Biol Interact. 2015. PMID: 25656918
Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.
Nirogi R, Palacharla RC, Uthukam V, Manoharan A, Srikakolapu SR, Kalaikadhiban I, Boggavarapu RK, Ponnamaneni RK, Ajjala DR, Bhyrapuneni G. Nirogi R, et al. Among authors: ponnamaneni rk. Xenobiotica. 2015 Feb;45(2):95-106. doi: 10.3109/00498254.2014.945196. Epub 2014 Jul 29. Xenobiotica. 2015. PMID: 25070627