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Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.
Qian Y, Hua E, Bisht K, Woditschka S, Skordos KW, Liewehr DJ, Steinberg SM, Brogi E, Akram MM, Killian JK, Edelman DC, Pineda M, Scurci S, Degenhardt YY, Laquerre S, Lampkin TA, Meltzer PS, Camphausen K, Steeg PS, Palmieri D. Qian Y, et al. Among authors: skordos kw. Clin Exp Metastasis. 2011 Dec;28(8):899-908. doi: 10.1007/s10585-011-9421-9. Epub 2011 Sep 21. Clin Exp Metastasis. 2011. PMID: 21953073 Free PMC article.
The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.
Grimm SW, Einolf HJ, Hall SD, He K, Lim HK, Ling KH, Lu C, Nomeir AA, Seibert E, Skordos KW, Tonn GR, Van Horn R, Wang RW, Wong YN, Yang TJ, Obach RS. Grimm SW, et al. Among authors: skordos kw. Drug Metab Dispos. 2009 Jul;37(7):1355-70. doi: 10.1124/dmd.109.026716. Epub 2009 Apr 9. Drug Metab Dispos. 2009. PMID: 19359406