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Page 1
A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor.
J Med Chem. 2001 Mar 15;44(6):917-22. doi: 10.1021/jm000275p.
J Med Chem. 2001.
PMID: 11300873
Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.
Debenham JS, Madsen-Duggan CB, Toupence RB, Walsh TF, Wang J, Tong X, Kumar S, Lao J, Fong TM, Xiao JC, Huang CR, Shen CP, Feng Y, Marsh DJ, Stribling DS, Shearman LP, Strack AM, Goulet MT.
Debenham JS, et al. Among authors: toupence rb.
Bioorg Med Chem Lett. 2010 Feb 15;20(4):1448-52. doi: 10.1016/j.bmcl.2009.12.065. Epub 2010 Jan 4.
Bioorg Med Chem Lett. 2010.
PMID: 20096577
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Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.
Madsen-Duggan CB, Debenham JS, Walsh TF, Toupence RB, Huang SX, Wang J, Tong X, Lao J, Fong TM, Schaeffer MT, Xiao JC, Huang CR, Shen CP, Stribling DS, Shearman LP, Strack AM, MacIntyre DE, Van der Ploeg LH, Goulet MT.
Madsen-Duggan CB, et al. Among authors: toupence rb.
Bioorg Med Chem Lett. 2007 Apr 1;17(7):2031-5. doi: 10.1016/j.bmcl.2007.01.005. Epub 2007 Jan 13.
Bioorg Med Chem Lett. 2007.
PMID: 17270441
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Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists.
Meurer LC, Finke PE, Mills SG, Walsh TF, Toupence RB, Debenham JS, Goulet MT, Wang J, Tong X, Fong TM, Lao J, Schaeffer MT, Chen J, Shen CP, Sloan Stribling D, Shearman LP, Strack AM, Van der Ploeg LH.
Meurer LC, et al. Among authors: toupence rb.
Bioorg Med Chem Lett. 2005 Feb 1;15(3):645-51. doi: 10.1016/j.bmcl.2004.11.031.
Bioorg Med Chem Lett. 2005.
PMID: 15664830
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Glutathione S-transferase catalyzed desulfonylation of a sulfonylfuropyridine.
Bateman TJ, Debenham JS, Madsen-Duggan C, Toupence RB, Walsh TF, Truong Q, Bradley SA, Doss GA, Kumar S, Reddy VB.
Bateman TJ, et al. Among authors: toupence rb.
Drug Metab Dispos. 2010 Jan;38(1):108-14. doi: 10.1124/dmd.109.029801.
Drug Metab Dispos. 2010.
PMID: 19797605
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Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides.
Walsh TF, Toupence RB, Young JR, Huang SX, Ujjainwalla F, DeVita RJ, Goulet MT, Wyvratt MJ Jr, Fisher MH, Lo JL, Ren N, Yudkovitz JB, Yang YT, Cheng K, Smith RG.
Walsh TF, et al. Among authors: toupence rb.
Bioorg Med Chem Lett. 2000 Mar 6;10(5):443-7. doi: 10.1016/s0960-894x(00)00024-x.
Bioorg Med Chem Lett. 2000.
PMID: 10743944
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