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Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities.
Haviv F, Bradley MF, Kalvin DM, Schneider AJ, Davidson DJ, Majest SM, McKay LM, Haskell CJ, Bell RL, Nguyen B, Marsh KC, Surber BW, Uchic JT, Ferrero J, Wang YC, Leal J, Record RD, Hodde J, Badylak SF, Lesniewski RR, Henkin J. Haviv F, et al. Among authors: uchic jt. J Med Chem. 2005 Apr 21;48(8):2838-46. doi: 10.1021/jm0401560. J Med Chem. 2005. PMID: 15828822
Implication of P450-metabolite complex formation in the nonlinear pharmacokinetics and metabolic fate of (+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in dogs.
Ferrero JL, Thomas SB, Marsh KC, Rodrigues AD, Uchic JT, Buko AM. Ferrero JL, et al. Among authors: uchic jt. Drug Metab Dispos. 2002 Oct;30(10):1094-101. doi: 10.1124/dmd.30.10.1094. Drug Metab Dispos. 2002. PMID: 12228185