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A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS.
van der Heijden LT, Gebretensae A, Thijssen B, van Andel L, Nijstad AL, Wang Y, Rosing H, Huitema ADR, Beijnen JH. van der Heijden LT, et al. Among authors: van andel l. J Pharm Biomed Anal. 2022 Jun 5;215:114772. doi: 10.1016/j.jpba.2022.114772. Epub 2022 Apr 16. J Pharm Biomed Anal. 2022. PMID: 35462284
Pharmacokinetics and excretion of 14C-Plitidepsin in patients with advanced cancer.
van Andel L, Fudio S, Rosing H, Munt S, Miguel-Lillo B, González I, Tibben MM, de Vries N, de Vries Schultink AHM, Schellens JHM, Beijnen JH. van Andel L, et al. Invest New Drugs. 2017 Oct;35(5):589-598. doi: 10.1007/s10637-017-0432-5. Epub 2017 Jan 23. Invest New Drugs. 2017. PMID: 28111728 Clinical Trial.
Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients.
Aviles P, Altares R, van Andel L, Lubomirov R, Fudio S, Rosing H, Márquez Del Pino FM, Tibben MM, Benedit G, Nan-Offeringa L, Luepke Estefan XE, Francesch A, Zeaiter A, Cuevas C, Schellens JHM, Beijnen JH. Aviles P, et al. Among authors: van andel l. Drug Metab Dispos. 2022 Apr;50(4):327-340. doi: 10.1124/dmd.121.000668. Epub 2022 Jan 18. Drug Metab Dispos. 2022. PMID: 35042701
Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.
van Andel L, Rosing H, Zhang Z, Hughes L, Kansra V, Sanghvi M, Tibben MM, Gebretensae A, Schellens JHM, Beijnen JH. van Andel L, et al. Cancer Chemother Pharmacol. 2018 Jan;81(1):39-46. doi: 10.1007/s00280-017-3455-x. Epub 2017 Oct 17. Cancer Chemother Pharmacol. 2018. PMID: 29043410 Free PMC article. Clinical Trial.
Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin.
van Andel L, Rosing H, Tibben MM, Lucas L, Lubomirov R, Avilés P, Francesch A, Fudio S, Gebretensae A, Hillebrand MJX, Schellens JHM, Beijnen JH. van Andel L, et al. Cancer Chemother Pharmacol. 2018 Sep;82(3):441-455. doi: 10.1007/s00280-018-3637-1. Epub 2018 Jul 4. Cancer Chemother Pharmacol. 2018. PMID: 29974200
The development and validation of a high performance liquid chromatography method to determine the radiochemical purity of [177Lu]Lu-HA-DOTA-TATE in pharmaceutical preparations.
van Andel L, Aalbersberg EA, Geluk-Jonker MM, Stokkel MPM, Beijnen JH, Hendrikx JJMA. van Andel L, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 May 1;1171:122605. doi: 10.1016/j.jchromb.2021.122605. Epub 2021 Feb 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33740691
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