Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide
secretion in steroid target tissues. In addition to the binding of these hormones to their receptors…

UDP-glucuronosyltransferase (UGT) enzymes belonging to the UGT2B subfamily catalyze
the transfer of glucuronic acid to a large number of endogenous compounds, particularly …

Conjugation of compounds by glucuronidation is a pathway found in all vertebrates studied
to date. Although, it is widely recognized that the liver is a major site of glucuronidation, it is …

In recent years, the enzymes which are involved in the formation of DHT in steroid target
tissues have been well investigated, however, enzymes responsible for the catabolism and …

Despite the importance of UDP-glucuronosyltransferase (UGT) 1A1*28 in irinotecan
pharmacogenetics, our capability to predict drug-induced severe toxicity remains limited. We aimed …

Glucuronidation by uridine diphospho‐glucuronosyltransferase enzymes (UGTs) is a major
phase II biotransformation pathway and, complementary to phase I metabolism and …

polymorphisms in the genes encoding phase II drug metabolizing UDP-glucuronosyltransferases
is still undescribed, despite the many reported cases of variations in glucuronidation …

Uridine diphospho glucuronosyltransferase 2B17 (UGT2B17) glucuronidates androgens and
xenobiotics including certain drugs. The UGT2B17 gene shows a remarkable copy number …

Variations in glucuronidation activities among different individuals have been reported;
however, genetic polymorphisms in the genes encoding phase II drug metabolizing UDP-…

Purpose: Prostate cancer is a heterogeneous genetic disease, and molecular methods for
predicting prognosis in patients with aggressive form of the disease are urgently needed to …