Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as
phenytoin,S-warfarin, tolbutamide, losartan, torasemide, and nonsteroidal anti-inflammatory drugs…

Background And Aim Losartan is metabolized by polymorphic CYP2C9 to E‐3174. Our aim
was to evaluate the pharmacokinetics of losartan and E‐3174 in relation to the CYP2C9 …

Losartan, an angiotensin II receptor antagonist, is oxidized by hepatic cytochromes P450 to
an active carboxylic acid metabolite, E-3174. The aim of the present investigation was to …

Introduction: The polymorphic cytochrome P 450 enzyme 2C9 (CYP2C9) catalyses the
metabolism of many drugs including S-warfarin, acenocoumarol, phenytoin, tolbutamide, losartan …

Aims Celecoxib is a novel selective cyclooxygenase‐2 inhibitor, which is subject to extensive
hepatic metabolism. The aims of the present in vitro investigation were 1) to compare the …

PURPOSE: A high degree of interindividual variation in cyclophosphamide (CPA)
pharmacokinetics was reported in certain cancer patient groups. To better understand the …

Objective This study analyzed the frequency of CYP2C9 variant alleles and evaluated the
impact of CYP2C9 genotype on diclofenac metabolism in a Spanish population. Methods …

Cytochromes P450 (CYP) 2C8 and 2C9 are polymorphic enzymes responsible for the
biosynthesis of vasoactive substances from arachidonic acid including endothelium-derived …

Several-fold differences have been observed among patients in the biotransformation of
cyclophosphamide. The aim of this study was to investigate the contribution of CYP2C9 and …

Objectives: Our objectives were (1) to determine whether the drugs caffeine, losartan,
omeprazole, debrisoquin (INN, debrisoquine), and quinine can be given simultaneously in low …