User profiles for A D Vaz

Aaron Darius Vaz

Assistant Professor, Department of Civil Engineering, Presidency University
Verified email at presidencyuniversity.in
Cited by 28

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis …

AD Vaz, SJ Pernecky, GM Raner… - Proceedings of the …, 1996 - National Acad Sciences
Among biological catalysts, cytochrome P450 is unmatched in its multiplicity of isoforms,
inducers, substrates, and types of chemical reactions catalyzed. In the present study, evidence …

Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects

…, R Sharma, V Mascitti, M Tugnait, AD Vaz… - Drug Metabolism and …, 2013 - ASPET
The disposition of ertugliflozin (PF-04971729), an orally active selective inhibitor of the
sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [ 14 C]-…

Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation.

ES Roberts, AD Vaz, MJ Coon - Proceedings of the …, 1991 - National Acad Sciences
As we have briefly described elsewhere, cytochrome P-450 catalyzes the oxidative
deformylation of cyclohexane carboxaldehyde to yield cyclohexene and formic acid in a reaction …

Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal.

ES Roberts, AD Vaz, MJ Coon - Molecular Pharmacology, 1992 - ASPET
The metabolism of retinoic acid, retinol, and retinal has been investigated with eight purified
rabbit cytochrome P-450 (P-450) isozymes, including the major forms in nasal and liver …

[PDF][PDF] Metabolism of all-trans, 9-cis, and 13-cis isomers of retinal by purified isozymes of microsomal cytochrome P450 and mechanism-based inhibition of retinoid …

GM Raner, AD Vaz, MJ Coon - Molecular Pharmacology, 1996 - Citeseer
The involvement of a series of microsomal cytochrome P450 (P450) isozymes in all-trans-retinoid
metabolism, including the conversion of all-trans-retinal to all-trans-retinoic acid, was …

Hydrocarbon formation in the reductive cleavage of hydroperoxides by cytochrome P-450.

AD Vaz, MJ Coon - Proceedings of the National Academy of …, 1987 - National Acad Sciences
Evidence is presented that cytochrome P-450 catalyzes the reductive cleavage of hydroperoxides.
For example, in a reconstituted system containing rabbit liver microsomal P-450 form 2…

Inactivation of ethanol-inducible cytochrome P450 and other microsomal P450 isozymes by trans-4-hydroxy-2-nonenal, a major product of membrane lipid …

LL Bestervelt, AD Vaz, MJ Coon - Proceedings of the …, 1995 - National Acad Sciences
Of the microsomal P450 cytochromes, the ethanol-inducible isoform, P450 2E1, is believed
to be predominant in leading to oxidative damage, including the generation of radical …

Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans

D Dalvie, W Chen, C Zhang, AD Vaz… - Drug metabolism and …, 2008 - ASPET
The pharmacokinetics, metabolism, and excretion of torcetrapib, a selective inhibitor of
human cholesteryl ester transfer protein, were investigated in healthy human male volunteers …

Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.

AD Vaz, ES Roberts, MJ Coon - Proceedings of the …, 1990 - National Acad Sciences
As shown previously in this laboratory, purified rabbit liver microsomal cytochrome P-450
form 2 (P-450 IIB4) catalyzes the reductive cleavage of hydroperoxides to yield hydrocarbons …

[PDF][PDF] Metabolic activation of 2, 6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.

X Ding, DC Spink, JK Bhama, JJ Sheng, AD Vaz… - Molecular …, 1996 - Citeseer
The herbicide 2, 6-dichlorobenzonitrile(DCBN) is known to cause tissue-specific toxicity at
very low doses in the olfactory mucosa of rodents. The toxicity of DCBN is reportedly …