User profiles for Aaron Teitelbaum

Aaron Alexander Teitelbaum

Lecturer and Instructor at Canadian Memorial Chiropractic College
Verified email at cmcc.ca
Cited by 345

Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

AA Teitelbaum, MG Gareau, J Jury… - American Journal …, 2008 - journals.physiology.org
Chronic psychological stress causes intestinal barrier dysfunction and impairs host defense
mechanisms mediated by corticotrophin-releasing factor (CRF) and mast cells; however, the …

Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science

…, CS Tautermann, AM Teitelbaum… - Journal of Medicinal …, 2023 - ACS Publications
Genome-wide association studies in patients revealed HSD17B13 as a potential new target
for the treatment of nonalcoholic steatohepatitis (NASH) and other liver diseases. However, …

Natural history of experimental arterial chronic total occlusions

…, J Lockwood, C Jacobs, B Qiang, A Teitelbaum… - Journal of the American …, 2009 - jacc.org
Objectives : We sought to perform the first systematic study of the natural history of chronic
total arterial occlusions (CTOs) in an experimental model. Background : Angioplasty of CTOs …

[HTML][HTML] Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity

…, M Aravantinou, T Miller, J Kenney, A Teitelbaum… - PloS one, 2008 - journals.plos.org
Anti-HIV microbicides are being investigated in clinical trials and understanding how promising
strategies work, coincident with demonstrating efficacy in vivo, is central to advancing …

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones

DJ Wilson, C Shi, AM Teitelbaum, AM Gulick… - Biochemistry, 2013 - ACS Publications
Aureusimines have been identified as potential virulence factors in Staphylococcus aureus.
These pyrazinone secondary metabolites are produced by a nonribosomal peptide …

Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High‐Throughput Screening

…, J Williams, DJ Wilson, AM Teitelbaum… - …, 2010 - Wiley Online Library
A simple steady‐state kinetic high‐throughput assay was developed for the salicylate
synthase MbtI from Mycobacterium tuberculosis, which catalyzes the first committed step of …

Intravascular and extravascular microvessel formation in chronic total occlusions: A micro-CT imaging study

…, J Lockwood, R Jaffe, J Butany, AA Teitelbaum… - JACC: Cardiovascular …, 2010 - jacc.org
Objectives : The purpose of this study was to characterize the 3-dimensional structure of
intravascular and extravascular microvessels during chronic total occlusion (CTO) maturation in …

[HTML][HTML] A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

…, J Kenney, M Piatak Jr, JD Lifson, A Teitelbaum… - PloS one, 2009 - journals.plos.org
Background Herpes simplex virus type-2 (HSV-2) infection enhances the transmission and
acquisition of human immunodeficiency virus (HIV). This occurs in symptomatic and …

Future of biotransformation science in the pharmaceutical industry

…, AS Kalgutkar, J O'Neill, D Su, AM Teitelbaum… - Drug Metabolism and …, 2022 - ASPET
Over the past decades, the number of scientists trained in departments dedicated to
traditional medicinal chemistry, biotransformation and/or chemical toxicology have seemingly …

Characterization of divergent metabolic pathways in elucidating an unexpected, slow-forming, and long half-life major metabolite of Iclepertin

…, KG Raymond, YS Scaringella, AM Teitelbaum… - Pharmaceutical …, 2023 - Springer
Purpose After single oral dosing of the glycine reuptake transporter (GlyT1) inhibitor, iclepertin
(BI 425809), a single major circulating metabolite, M530a, was identified. However, upon …