User profiles for Adarsh Gandhi

Adarsh Gandhi

Lundbeck Research USA Inc.
Verified email at uh.edu
Cited by 1054

Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

R Ghose, O Omoluabi, A Gandhi, P Shah, K Strohacker… - Life sciences, 2011 - Elsevier
Aim Our aim is to investigate the molecular mechanism of regulation of gene expression of
drug metabolizing enzymes (DMEs) and transporters in diet-induced obesity. Main methods …

Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry

A Wohlfarth, AS Gandhi, S Pang, M Zhu… - Analytical and …, 2014 - Springer
Background PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl
ester-1H-indole-3-carboxylic acid) are new synthetic …

First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry

A Wohlfarth, S Pang, M Zhu, AS Gandhi… - Clinical …, 2013 - academic.oup.com
BACKGROUND Since the mid-2000s synthetic cannabinoids have been abused as
recreational drugs, prompting scheduling of these substances in many countries. To circumvent …

First characterization of AKB-48 metabolism, a novel synthetic cannabinoid, using human hepatocytes and high-resolution mass spectrometry

AS Gandhi, M Zhu, S Pang, A Wohlfarth… - The AAPS journal, 2013 - Springer
Since the federal authorities scheduled the first synthetic cannabinoids, JWH-018 and JWH-073,
new synthetic cannabinoids were robustly marketed. N-(1-Adamantyl)-1-pentylindazole-…

Drug disposition in pathophysiological conditions

A Gandhi, B Moorthy, R Ghose - Current drug metabolism, 2012 - ingentaconnect.com
Expression and activity of several key drug metabolizing enzymes (DMEs) and transporters
are altered in various pathophysiological conditions, leading to altered drug metabolism and …

High‐resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS …

AS Gandhi, A Wohlfarth, M Zhu, S Pang… - Drug testing and …, 2015 - Wiley Online Library
N‐(Adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135) is a new
synthetic cannabinoid in herbal incense products discussed on Internet drug user forums and …

Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-α) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) …

A Gandhi, T Guo, R Ghose - The Journal of toxicological sciences, 2010 - jstage.jst.go.jp
Drug induced liver injury (DILI) accounts for more than 50% of the cases of acute liver failure
in this country, and is the major cause of drug withdrawal from the market. DILI has been …

Quantitative analysis of lipids: a higher-throughput LC–MS/MS-based method and its comparison to ELISA

AS Gandhi, D Budac, T Khayrullina, R Staal… - Future science …, 2017 - Future Science
Aim: Lipids such as prostaglandins, leukotrienes and thromboxanes are released as a result
of an inflammatory episode in pain (central and peripheral). Methodology & results: To …

Quantitative urine confirmatory testing for synthetic cannabinoids in randomly collected urine specimens

…, KB Scheidweiler, A Gandhi… - Drug Testing and …, 2015 - Wiley Online Library
Synthetic cannabinoid intake is an ongoing health issue worldwide, with new compounds
continually emerging, making drug testing complex. Parent synthetic cannabinoids are rarely …

Synthesis and characterization of the novel rodent-active and CNS-penetrant P2X7 receptor antagonist Lu AF27139

…, H Zhang, M Cajina, ME Nattini, A Gandhi… - Journal of Medicinal …, 2021 - ACS Publications
There remains an insufficient number of P2X7 receptor antagonists with adequate rodent
potency, CNS permeability, and pharmacokinetic properties from which to evaluate CNS …