User profiles for Adarsh Gandhi
Adarsh GandhiLundbeck Research USA Inc. Verified email at uh.edu Cited by 1054 |
Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters
Aim Our aim is to investigate the molecular mechanism of regulation of gene expression of
drug metabolizing enzymes (DMEs) and transporters in diet-induced obesity. Main methods …
drug metabolizing enzymes (DMEs) and transporters in diet-induced obesity. Main methods …
Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry
A Wohlfarth, AS Gandhi, S Pang, M Zhu… - Analytical and …, 2014 - Springer
Background PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl
ester-1H-indole-3-carboxylic acid) are new synthetic …
ester-1H-indole-3-carboxylic acid) are new synthetic …
First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry
A Wohlfarth, S Pang, M Zhu, AS Gandhi… - Clinical …, 2013 - academic.oup.com
BACKGROUND Since the mid-2000s synthetic cannabinoids have been abused as
recreational drugs, prompting scheduling of these substances in many countries. To circumvent …
recreational drugs, prompting scheduling of these substances in many countries. To circumvent …
First characterization of AKB-48 metabolism, a novel synthetic cannabinoid, using human hepatocytes and high-resolution mass spectrometry
AS Gandhi, M Zhu, S Pang, A Wohlfarth… - The AAPS journal, 2013 - Springer
Since the federal authorities scheduled the first synthetic cannabinoids, JWH-018 and JWH-073,
new synthetic cannabinoids were robustly marketed. N-(1-Adamantyl)-1-pentylindazole-…
new synthetic cannabinoids were robustly marketed. N-(1-Adamantyl)-1-pentylindazole-…
Drug disposition in pathophysiological conditions
Expression and activity of several key drug metabolizing enzymes (DMEs) and transporters
are altered in various pathophysiological conditions, leading to altered drug metabolism and …
are altered in various pathophysiological conditions, leading to altered drug metabolism and …
High‐resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS …
AS Gandhi, A Wohlfarth, M Zhu, S Pang… - Drug testing and …, 2015 - Wiley Online Library
N‐(Adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135) is a new
synthetic cannabinoid in herbal incense products discussed on Internet drug user forums and …
synthetic cannabinoid in herbal incense products discussed on Internet drug user forums and …
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-α) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) …
Drug induced liver injury (DILI) accounts for more than 50% of the cases of acute liver failure
in this country, and is the major cause of drug withdrawal from the market. DILI has been …
in this country, and is the major cause of drug withdrawal from the market. DILI has been …
Quantitative analysis of lipids: a higher-throughput LC–MS/MS-based method and its comparison to ELISA
AS Gandhi, D Budac, T Khayrullina, R Staal… - Future science …, 2017 - Future Science
Aim: Lipids such as prostaglandins, leukotrienes and thromboxanes are released as a result
of an inflammatory episode in pain (central and peripheral). Methodology & results: To …
of an inflammatory episode in pain (central and peripheral). Methodology & results: To …
Quantitative urine confirmatory testing for synthetic cannabinoids in randomly collected urine specimens
…, KB Scheidweiler, A Gandhi… - Drug Testing and …, 2015 - Wiley Online Library
Synthetic cannabinoid intake is an ongoing health issue worldwide, with new compounds
continually emerging, making drug testing complex. Parent synthetic cannabinoids are rarely …
continually emerging, making drug testing complex. Parent synthetic cannabinoids are rarely …
Synthesis and characterization of the novel rodent-active and CNS-penetrant P2X7 receptor antagonist Lu AF27139
…, H Zhang, M Cajina, ME Nattini, A Gandhi… - Journal of Medicinal …, 2021 - ACS Publications
There remains an insufficient number of P2X7 receptor antagonists with adequate rodent
potency, CNS permeability, and pharmacokinetic properties from which to evaluate CNS …
potency, CNS permeability, and pharmacokinetic properties from which to evaluate CNS …