In vitro permeability experiments are used widely in drug discovery and other areas of
pharmaceutical research. Much effort has been expended in developing novel epithelial models …

Physiologically based pharmacokinetic modelling is well established in the pharmaceutical
industry and is accepted by regulatory agencies for the prediction of drug–drug interactions. …

Oral administration is the most common route for drug administration. However, after oral
administration, the absorption may be erratic and incomplete. P-glycoprotein, an efflux …

Arginine, phenylalanine, and tryptophan have been previously shown to improve the solid-state
stability of amorphous indomethacin. The present study investigates the ability of these …

First pass metabolism in the intestinal mucosa is a determinant of oral bioavailability of CYP3A
substrates and so the prediction of intestinal availability (Fg) of potential drug candidates …

Oral delivery is the preferred route of administration and therefore good absorption after oral
dosing is a prerequisite for a compound to be successful in the clinic. The prediction of oral …

Purpose Beagle dogs are used to study oral pharmacokinetics and guide development of
drug formulations for human use. Since mechanistic insight into species differences is needed …

Purpose To elucidate the apical and basolateral components of the total unstirred water layer
in regular permeability experiment. Methods A novel stirring apparatus was constructed to …

Uridine 5′-diphospho-glucuronosyltransferases (UGTs) are expressed in the small intestines,
but prediction of first-pass extraction from the related metabolism is not well studied. This …

Pharmacokinetics (PK) refers to the time course of drug concentrations in the body and since
knowledge of PK aids understanding of drug efficacy and safety, numerous PK studies are …