Schizophrenia is a debilitating mental illness that affects 1% of the population. Despite
intensive study, its molecular etiology remains enigmatic. Like many common diseases, …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating
to the nucleus during apoptosis. Here we report a signalling pathway in which nitric oxide (…

Copy number variants (CNVs) are major contributors to genetic disorders 1 . We have
dissected a region of the 16p11.2 chromosome—which encompasses 29 genes—that confers …

Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a
chromosomal translocation that is linked to a rare familial schizophrenia, has been genetically …

Recent studies suggested that microglia, the primary brain immune cells, can affect circuit
connectivity and neuronal function 1 , 2 . Microglia infiltrate the neuroepithelium early in …

Environmental stressors during childhood and adolescence influence postnatal brain
maturation and human behavioral patterns in adulthood. Accordingly, excess stressors result in …

Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …

BACKGROUND: Glutamate has been thought to have a role in mental disorders. Because
the postmortem interval (PMI) has such a pronounced effect on glutamate and other amino …

Disrupted-in-Schizophrenia-1 (DISC-1) is a gene whose mutant truncation is associated with
major psychiatric illness with a predominance of schizophrenic symptomatology. We have …

We present evidence for a specific role of p53 in the mitochondria-associated cellular
dysfunction and behavioral abnormalities of Huntington's disease (HD). Mutant huntingtin (mHtt) …