Drug metabolizing enzymes in the brain and cerebral microvessels

A Minn, JF Ghersi-Egea, R Perrin, B Leininger… - Brain Research …, 1991 - Elsevier
Several families of brain parenchyma and microvessel endothelial cell enzymes can metabolize
substrates of exogenous origin. This xenobiotic metabolism includes functionalization …

Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier

A Minn, S Leclerc, JM Heydel, AL Minn… - Journal of drug …, 2002 - Taylor & Francis
It is generally accepted that the rate of entry into and distribution of drugs and other xenobiotics
within the central nervous system (CNS) depends on the particular anatomy of the brain …

Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain.

RS El-Bachá, A Minn - Cellular and molecular biology (Noisy-le …, 1999 - europepmc.org
The brain is partially protected from chemical insults by a physical barrier mainly formed by
the cerebral microvasculature, which prevents penetration of hydrophilic molecules in the …

Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain

…, C Jeandel, J Floquet, G Cuny, G Siest, A Minn - Biochemical …, 1993 - Elsevier
We studied the subcellular distribution of cytochrome P450 and related monooxygenase
activities in six regions of human brains removed at autopsy. The content of total cytochrome …

Pefloxacin-induced Achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen

MA Simonin, P Gegout-Pottie, A Minn… - Antimicrobial Agents …, 2000 - Am Soc Microbiol
Despite a relatively low incidence of serious side effects, fluoroquinolones and the fluoroquinolone
pefloxacin have been reported to occasionally promote tendinopathy that might result …

A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels

JF Ghersi-Egea, A Minn, G Siest - Life sciences, 1988 - Elsevier
The multiple functions of the blood-brain barrier (BBB) consist mostly in membrane properties
controlling the bidirectional exchange of molecules between the general circulation and …

Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier

P Lagrange, IA Romero, A Minn, PA Revest - Free Radical Biology and …, 1999 - Elsevier
In the present study, we investigated the changes in blood-brain barrier (BBB) permeability
following brain endothelial cell exposure to different xenobiotics able to promote free radical …

Glucuronidation of odorant molecules in the rat olfactory system. Activity, expression and age-linked modifications of UDP-glucuronosyltransferase isoforms, UGT1A6 …

…, J Magdalou, P Netter, H Pelczar, A Minn - Molecular brain …, 2002 - Elsevier
The aim of the present study was to examine the glucuronidation of a series of odorant
molecules by homogenates prepared either with rat olfactory mucosa, olfactory bulb or brain. …

Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study

R Perrin, S Briançon, C Jeandel, Y Artur, A Minn… - Gerontology, 1990 - karger.com
Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which
are the three main enzymes involved in cellular protection against damage due to oxygen-…

Evidence for neurogenic transmission inducing degenerative cartilage damage distant from local inflammation

…, M Chat, L Philippe, JP Grillasca, A Minn… - … : Official Journal of …, 1999 - Wiley Online Library
Objective To investigate involvement of the nervous system in ipsilateral and contralateral
joint inflammation. Methods Freund's complete adjuvant (CFA; 1 mg or 1 μg) was injected …