Improving the stability of proteins is an important goal in many biomedical and industrial
applications. A logical approach is to emulate stabilizing molecular interactions found in nature. …

Recent advances in the biology of stem cells has resulted in significant interest in the
development of normal epithelial cell lines from the intestinal mucosa, both to exploit the …

Background Disulfide engineering is an important biotechnological tool that has advanced
a wide range of research. The introduction of novel disulfide bonds into proteins has been …

Disulfide by Design is a program for the design of novel disulfide bonds in proteins. Protein
structure files in PDB format are analyzed to identify residue pairs that are likely to form a …

Sex-differences in human liver gene expression were characterized on a genome-wide scale
using a large liver sample collection, allowing for detection of small expression differences …

Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di-and
trimethylation marks, plays critical roles in controlling transcription and chromatin architecture…

Hepatocyte nuclear factor (HNF)-4α is a liver-enriched transcription factor that regulates
numerous liver-expressed genes including several sex-specific cytochrome P450 genes. …

The goal of the present study is to unveil the gene expression profile specific to the biological
processes of human breast epithelial cell invasion and migration using an MCF10A model …

Sex differences in liver gene expression are dictated by sex differences in circulating GH
profiles. Presently, the pituitary hormone dependence of mouse liver gene expression was …

RUNX1 (AML1) encodes the core binding factor α subunit of a heterodimeric transcription
factor complex which plays critical roles in normal hematopoiesis. Translocations or down-…