Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole:  Prodrugs for the Enolic OH Group

…, EF Fiese, DL Johnson, AV Kuperman… - Journal of Medicinal …, 1996 - ACS Publications
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and
screened as potential prodrugs of 1. This effort led to the discovery of the (α-l-alanyloxy)…

Preclinical pharmacokinetics and metabolism of 6‐(4‐(2,5‐difluorophenyl)oxazol‐5‐yl)‐3‐isopropyl‐[1,2,4]‐triazolo[4,3‐a]pyridine, a novel and selective p38α …

…, TJ Taylor, KR Henne, AV Kuperman… - … & drug disposition, 2006 - Wiley Online Library
The disposition of 6‐(4‐(2,5‐difluorophenyl)oxazol‐5‐yl)‐3‐isopropyl‐[1,2,4]‐triazolo[4,3‐a]pyridine
(1), a potent and selective inhibitor of mitogen activated protein (MAP) kinase p38α, …

Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development

…, CP Gibbons, CK Jordan, AV Kuperman… - Bioorganic & medicinal …, 2006 - Elsevier
The synthesis, structure–activity relationship, in vivo activity, and metabolic profile for a series
of triazolopyridine-oxazole based p38 inhibitors are described. The deficiencies of the lead …

High-temperature sulfidic corrosion of carbon steel in model oil/sulfur compound blends

…, DR Chapman, B Chaloner-Gill, AE Kuperman - NACE …, 2017 - onepetro.org
Sulfidic corrosion of steels is defined as a high temperature (=450F/232C) degradation
phenomenon that occurs in oil containing sulfur species. Over the last few decades, many …

Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender …

AV Kuperman, AS Kalgutkar, A Marfat… - Drug metabolism and …, 2001 - ASPET
CP-199,331 is a potent antagonist of the cysteinyl leukotriene-1 (LT 1 ) receptor, targeted for
the treatment of asthma. The pharmacokinetic/metabolism properties of CP-199,331 were …

Impact resistance of reinforced plastics based on polysulfone-epoxy blends

…, ES Zelenskii, AM Kuperman - Journal of reinforced …, 2003 - journals.sagepub.com
The low velocity impact behavior of composites based on polysulfone, epoxy resin and
polysulfone-epoxy blends (5 and 10% polysulfone) was investigated. Glass and carbon …

Correction to Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group

…, EF Fiese, DL Johnson, AV Kuperman… - Journal of Medicinal …, 2018 - ACS Publications
Correction to Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of
an Antirheumatic Oxindole: Prodrugs Page 1 Correction to Discovery of the Hemifumarate …

Control of Zeta Potential of Hierarchical Mesoporous Zeolite Y via Inorganic Surface Modification without Micropore Blockage and Phase Separation

…, T Rea, K Chaudhuri, J Han, A Kuperman… - Crystal Growth & …, 2023 - ACS Publications
We describe a selective postsynthetic surface modification of the interior surface of
mesoporous Y zeolite (Meso-Y), which results in a uniform nanoscale silica, alumina, or …

Alkyl–aryl coupling catalyzed by tandem systems of pincer-ligated iridium complexes and zeolites

…, B Li, A Kumar, W Schinski, KD Field, A Kuperman… - ACS …, 2016 - ACS Publications
We report that pincer-ligated iridium catalysts for alkane dehydrogenation can operate in
tandem with zeolite catalysts for arene–alkene coupling, to effect the overall intramolecular …

Supramolecular approaches for pore expansion in mesoporous Y zeolites

X Li, A Martinez, A Kuperman, J Han, A Katz - … and Mesoporous Materials, 2024 - Elsevier
With a motivation of improving accessibility for mass transport of sterically bulky molecules,
we demonstrate the synthesis of mesoporous Y zeolite catalysts with increased pore size. …