… , Ian Kerr, Timothy Dafforn and Alice Rothnie performed the experiments. Robert Ford,
Timothy Dafforn and Alice Rothnie analysed the data. Alice Rothnie, Michael Overduin and Ian …

… Patel, Victor Odiba, Masood Javed, Nikola Chmel and Alice Rothnie performed the
experiments. Alice Rothnie and Nikola Chmel analysed the data. Alice Rothnie wrote the paper. …

The use of styrene maleic acid co-polymer (SMA) for membrane protein extraction and
purification has grown in recent years. SMA inserts in the membrane and assembles into small …

In tumour cell lines that display multidrug resistance, expression of P-glycoprotein (P-gp)
alters many aspects of biomembrane organization in addition to its well-characterized drug …

The fundamental importance of membrane proteins in drug discovery has meant that membrane
mimetic systems for studying membrane proteins are of increasing interest. One such …

New technologies for the purification of stable membrane proteins have emerged in recent
years, in particular methods that allow the preparation of membrane proteins with their native …

… Bill, Anass Jawhari, Alice J. Rothnie; Overcoming bottlenecks in the membrane protein
structural biology pipeline. Biochem Soc Trans 15 June 2016; 44 (3): 838–844. doi: https://doi.org/…

Drug export from cells is a major factor in the acquisition of cellular resistance to antimicrobial
and cancer chemotherapy, and poses a significant threat to future clinical management of …

The production of membrane proteins of high purity and in satisfactory yields is crucial for
biomedical research. Due to their involvement in various cellular processes, membrane …

Historically, recombinant membrane protein production has been a major challenge meaning
that many fewer membrane protein structures have been published than those of soluble …