The cytochrome P450-derived epoxyeicosatrienoic acids (EETs) have potent effects on
renal vascular reactivity and tubular sodium and water transport; however, the role of these …

The stability of cytochrome P450 enzymes, cytochrome b 5 , and NADPH–cytochrome c
reductase was examined in (A) human liver samples frozen in liquid nitrogen and stored at −80C…

Nine organic solvents and 47 commonly used P450 substrates and inhibitors were examined
for their effects on coumarin 7-hydroxylase (CYP2A6) activity in human liver microsomes. …

In an advanced environmental chemistry course, the inclusion of semester-long scientific
service projects successfully integrated the research process with course content. Each project …

Leukotoxin (9,10-epoxy-12-octadecanoate) and isoleukotoxin (12,13-epoxy-9-octadecenoate)
are monoepoxides of linoleic acid, synthesized by a cytochrome P450 monooxygenase …

The major pathway of testosterone oxidation by human liver microsomes is the formation of
6β-hydroxytestosterone, which is catalyzed by CYP3A4/5 and which accounts for 75–80% of …

Inhibition of xenobiotic-metabolizing enzymes by metals may represent an important
mechanism in regulating enzyme activity. Fourteen cations were evaluated for inhibition of …

Soluble epoxide hydrolase (sEH) is a ubiquitous mammalian enzyme for which liver and
kidney are reported to have the highest activity. We have shown that the soluble epoxide …

The activity of liver microsomal CYP2E1 is commonly measured as the rate of 5-chloro-2-benzoxazolone
(chlorzoxazone) 6-hydroxylation, which requires separation of 6-…

… Last, but by no means least, I would like to thank my parents, Donald and Judy Draper, and
my brother, Nathan Draper, for their love and unending encouragement, and for continuing to …