Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats.
KC Cundy, AM Bidgood, G Lynch, JP Shaw… - Drug metabolism and …, 1996 - ASPET
The pharmacokinetics, distribution, and metabolism of [14C]cidofovir and its cyclic analog {[2-14C]-1-[((S)-2-hydroxy-2-oxo-1,4,
2-dioxaphosphorinan-5-yl)methyl]cytosine; [14C]cyclic …
2-dioxaphosphorinan-5-yl)methyl]cytosine; [14C]cyclic …
Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats
…, MN Arimilli, RJ Jones, AM Bidgood… - Drug metabolism and …, 1997 - ASPET
The oral bioavailability of PMEA (9-[2-(phosphonomethoxy)ethyl]adenine; adefovir) has been
determined in rats from three bis-ester prodrugs of PMEA: bis-(pivaloyloxymethyl) PMEA (…
determined in rats from three bis-ester prodrugs of PMEA: bis-(pivaloyloxymethyl) PMEA (…
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase
…, A Hashash, SH Krawczyk, AM Bidgood… - Antimicrobial agents …, 2013 - Am Soc Microbiol
GS-9669 is a highly optimized thumb site II nonnucleoside inhibitor of the hepatitis C virus (HCV)
RNA polymerase, with a binding affinity of 1.35 nM for the genotype (GT) 1b protein. It …
RNA polymerase, with a binding affinity of 1.35 nM for the genotype (GT) 1b protein. It …
Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat
DJ Sweeny, G Lynch, AM Bidgood, W Lew… - Drug metabolism and …, 2000 - ASPET
The metabolism of [2-acetyl- 14 C]oseltamivir (GS4104, Ro 64-0796), the prodrug of the novel
influenza neuraminidase inhibitor GS4071 (Ro 64-0802), was examined in rats after oral …
influenza neuraminidase inhibitor GS4071 (Ro 64-0802), was examined in rats after oral …
Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions
DG Musson, AM Bidgood, O Olejnik - Journal of Chromatography B …, 1991 - Elsevier
Prednisolone, prednisolone acetate and prednisolone sodium phosphate are glucocorticoids
used for ocular, anti-inflammatory therapy. A reversed-phase high-performance liquid …
used for ocular, anti-inflammatory therapy. A reversed-phase high-performance liquid …
Isolation and identification of a metabolite of cidofovir from rat kidney
EJ Eisenberg, GR Lynch, AM Bidgood… - … of pharmaceutical and …, 1998 - Elsevier
Cidofovir is an acyclic nucleotide analog with potent and broad-spectrum antiviral activity
against adenoviruses and herpesviruses including cytomegalovirus (CMV). Cidofovir …
against adenoviruses and herpesviruses including cytomegalovirus (CMV). Cidofovir …
Stabilization of aqueous thymoxamine using dimethyl-β-cyclodextrin
DG Musson, DP Evitts, AM Bidgood… - International journal of …, 1993 - Elsevier
Moxisylyte (or thymoxamine) is an α-adrenoceptor blocking agent used to reverse mydriasis.
The drug molecule has an ester moiety which is vulnerable to acid and base catalyzed …
The drug molecule has an ester moiety which is vulnerable to acid and base catalyzed …
Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104
EJ Eisenberg, A Bidgood… - Antimicrobial agents and …, 1997 - Am Soc Microbiol
GS4071 is a novel potent inhibitor of influenza neuraminidase (Ki < 1 nM) with low (< 5%)
oral bioavailability in animals. An ethyl ester prodrug of GS4071, GS4104, has exhibited good …
oral bioavailability in animals. An ethyl ester prodrug of GS4071, GS4104, has exhibited good …
Trends in national surveillance for rabies among bats in the United States (1993–2000)
Objective —To describe surveillance trends and epidemiologic features of rabies in bats in
the United States, focusing on 3 bat species primarily associated with variants of the rabies …
the United States, focusing on 3 bat species primarily associated with variants of the rabies …
Increased ocular opacity and swelling associated with the left eye of a mare
CN Buckley, C Tollefson, MR Telle… - Journal of the American …, 2024 - Am Vet Med Assoc
Based on the ophthalmologic examination, the patient was diagnosed with diffuse corneal
edema with secondary corneal ulcerations from corneal bulla rupture and secondary reflex …
edema with secondary corneal ulcerations from corneal bulla rupture and secondary reflex …